结构速递 | 一周“结构”要览 VOL.84(10.09~10.15)
上周发布了哪些“结构”文章？又取得了哪些科研进展？
结构速递栏目以每周“结构”相关领域刊文为主题，梳理一周结构发文大事记，“结构速递”为您传递最新、最快、最权威的结构资讯。
2023.10.09~2023.10.15
CNS刊登文章
01
Nature
2023/10/11
“Structures illustrate step-by-step mitochondrial transcription initiation”
转录起始是基因表达中的一个关键调控步骤，在这一过程中，RNA聚合酶（RNAP）从头开始合成RNA，并在特定长度的合成RNA触发过渡到延伸阶段。线粒体招募了一个单亚基RNAP和一个或两个辅助因子来启动转录。之前的研究已经揭示了酵母和人类线粒体RNAP起始复合物（ICs）的分子结构。
来自比利时吕汶大学的Kalyan Das和美国新泽西州皮斯卡塔韦市罗格斯大学的Smita S. Patel通过解析酵母线粒体RNAP和转录因子Mtf1的高分辨率冷冻电镜（cryo-EM）结构，提供了转录起始的全面、逐步机制，该机制在单核苷酸添加步骤中催化了2到8-核苷酸的RNA合成。不断增长的RNA-DNA在模板收缩和非模板重组的作用下适应于聚合酶缝隙中，形成了中间体。在早期起始阶段，非模板链的收缩和展开破坏了短的2到3-核苷酸的RNA合成，触发了合成失败。随后，非模板重新组织成一个基础堆叠的楼梯状结构，支持连续合成5到8-核苷酸的RNA。IC8中扩展的非模板阶梯和高度收缩的模板破坏了与Mtf1的启动子相互作用，从而促使启动子泡的破裂和启动子逃逸，完成了从起始到延伸复合物（EC）的过渡。一系列的转录起始步骤，每个步骤都由多个结构组分的相互作用引导，揭示了潜在的调控控制的精细调节机制。
原文链接
https://www.nature.com/articles/s41586-023-06643-y
Science
本周无
Cell
本周无
2023.10.09~2023.10.15
子刊刊登文章
01
Molecular Cell
10.10
1.“The structural mechanism of dimeric DONSON in replicative helicase activation”
10.12
2.“Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2”
02
Nature Communications
10.10
1.“HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes”
10.10
2. “Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2”
10.10
3.“Cryo-EM structure of severe fever with thrombocytopenia syndrome virus”
10.10
4.“A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes”
10.10
5. “Structure of native chromatin fibres revealed by Cryo-ET in situ”
10.11
6.“A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1”
10.11
7.“Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A”
10.11
8.“Asymmetric gating of a human hetero-pentameric glycine receptor”
10.11
9.“Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo”
10.11
10.“Structural basis of promiscuous substrate transport by Organic Cation Transporter 1”
10.12
11.“KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors”
10.12
12.“Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A”
10.13
13.“Cryo-EM structure of cyanophage P-SCSP1u offers insights into DNA gating and evolution of T7-like viruses”
10.13
14.“Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility”
10.13
15.“Molecular mechanism of decision-making in glycosaminoglycan biosynthesis”
10.13
16.“Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410”
10.13
17.“Structural insights into the allosteric inhibition of P2X4 receptors”
10.13
18.“Structure of the transcription open complex of distinct σI factors”
10.14
19.“Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes”
03
Science Advances
10.13
1.“Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding”
10.13
2.“The cryo-EM structure of the human ERAD retrotranslocation complex”
10.13
3.“Atomic structure of the open SARS-CoV-2 E viroporin”
Cell Research
本周无
Nature Structural & Molecular Biology
本周无
作者 | 谭佳鑫
审稿 | 肖媛
责编 | 囡囡
设计、排版 | 可洲
本着相互学习、共同进步的原则中心建立了一个生物结构前沿学术交流群，欢迎您扫码加入我们
推荐阅读
点击上方卡片
关注我们吧
END
我知道你“在看”哟